Sema4 to exit reproductive well being testing, lay off 500

AI-backed genomic and scientific knowledge firm Sema4 introduced this week it could exit the reproductive well being testing enterprise, shut down its lab in Stamford, Conn., and lay off about 500 staff.

The corporate stated it could full its departure from the section within the first quarter subsequent 12 months. It should now make use of about 1,100 employees. Based on a WARN Act Notice filed in Connecticut, the cuts have an effect on 206 staff who report back to its headquarters in Stamford, 227 who work within the Stamford lab and 15 from its Branford lab. 

The most recent layoffs come months after Sema4 cut around 250 staffers, then round 13% of its workforce, as a part of one other restructuring. Mixed with layoffs from earlier this 12 months, Sema4 stated in August it had minimize about 30% of its jobs from its legacy enterprise.

By eliminating the reproductive well being section, the corporate will double down on its GeneDx exome and entire genome sequencing service and its Centrellis knowledge platform. Sema4, which acquired GeneDx earlier this 12 months, is pitching the deal with these choices as a technique to attain profitability, which it now expects in 2025. 

“We imagine that our targeted industrial and R&D efforts present the correct basis for us to focus on greater development areas of the genomics market and optimize our knowledge and well being insights go-to-market technique,” Katherine Stueland, president and CEO of Sema4, stated in a press release. “We anticipate the mixture of those efforts will assist us develop income in extra of 20% over the subsequent a number of years. We additionally anticipate the actions we have now undertaken will allow us to greater than double our run price gross margin profile exiting the third quarter and cut back our annual money burn by better than 50% in 2023.”


Sema4 was spun out from Mount Sinai Health System in 2017 and hit the general public markets by a merger with a special purpose acquisition company final 12 months.  

Alongside the summer time job cuts, founder Eric Schadt, who had been with the corporate because it spun off, left his roles as president and chief analysis and growth officer, in addition to his place as director of the corporate.

Sema4 additionally posted outcomes for the third quarter that ended September 30. It reported income of $83.2 million in comparison with $43.2 million within the prior-year interval. The corporate posted a internet lack of $77.6 million, in contrast with revenue of $32.7 million last year.

Sema4 stated it’ll keep its full-year income steerage of $245 to 255 million. 

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